I’m a 67 yr old IBS-C sufferer for 2 yrs. After using Linzess unsuccessfully and having worse issues, i’ve found my solution. Every AM I take SAMe, 200 mgs; Jarrow methyl b12, methyl folate plus p5p(b6); Pro-50 probiotic, 2 capsules; 1 capsule L glutamine (NOW); magnesium 1 250 mg gelcap: 2/3 scoop Prebiotin Probiotic in warm water with 1 tsp ground flaxseed. I also follow a modified gluten free diet several days a week. I always take 500 mgs of magnesium (2 gel caps) before bed. In pm, if needed, I use Metamucil, 1 tsp. Btw add fiber. Popcorn is a great snack and provides extra fiber. This is my solution. I hope it can help someone.