Medications for IBS

Use of medications (drugs), whether prescription, over-the-counter, herbs, or supplements should be considered carefully and in consultation with your healthcare provider.

Irritable bowel syndrome (IBS) is a disorder characterized by two key elements:
1. An abdominal component generally described as pain/discomfort and
2. Alterations in bowel, habits including changes in stool texture and/or frequency.

Pharmacologic, or drug, therapy is best used in irritable bowel syndrome (IBS) patients with moderate to severe symptoms which do not respond to physician counseling and dietary changes.

What is a medication?

Anything you take for a therapeutic effect counts as a medicine. It can be readily available over-the-counter, in a pharmacy or grocery store, or limited by prescription only. It might be a drug or a supplement; manufactured or “natural.” It might come in a pill, a liquid, or a food product. When you take something for a long-term therapeutic effect, tell your doctor about it. He or she can help you monitor quality, effectiveness, possible interactions with other medicines you may be taking, or possible side effects.

Remember, all medicines have potential side effects. Before taking any medication, whether over the counter or prescription, talk to your healthcare provider or pharmacist about dosage, other medicines you are taking, or any other questions you might have about the treatment. Otherwise, carefully follow the directions on the drug package or on your prescription label.

Medications for IBS

First line treatment has traditionally been aimed at treating the most bothersome symptom because of the lack of effective treatment for the overall improvement of multiple symptoms in IBS patients. However, new therapies for IBS have been recently introduced and have been shown to effectively treat multiple symptoms of IBS.

Laxatives – a drug that increases bowel function. There are many laxatives available without a prescription. 

Read more about laxatives.

Secretagogues/Prosecretory agents are a class of drugs which increase fluid secretion and movement in the GI tract. These drugs also can improve pain, discomfort, and bloating. Currently there are 4 FDA approved treatments in this class: lubiprostone, linaclotide, plecanatide, and tenapenor.

Bulking agents­ – provided they relieve and don’t worsen symptoms, they can ease stool passage. Examples include bran and psyllium.

Anticholinergics/Antispasmodics – have limited benefit for treating IBS. In some persons they relieve abdominal pain or discomfort, usually if the symptoms occur soon after eating. Examples are dicyclomine (Bentyl), and hyoscyamine (Levsin).

Read more about anticholinergics/antispasmodics.

Anti-diarrheal agents – are drugs which slow gut transit. Transit refers to the amount of time it takes for materials to move through the gut. They also decrease intestinal secretion (movement of fluid into the intestines) and increase the amount of fluid that is reabsorbed by the gastrointestinal (GI) tract.  

Read more about antidiarrheal agents.

Anti-anxiety medications – can be helpful for some people with IBS, mainly those with emotional distress.

There are also effective medications available that relieve pain and improve the changes in bowel habit. They include low-dose antidepressant agents which may need to be taken on a more long-term basis. These include low dose antidepressant agents or the relatively newer medications.

Antidepressants – The use of antidepressant drugs in low doses for treating IBS symptoms is not linked to depression per se, but rather likely to their effects on the brain and the gut. Antidepressant medications can reduce the intensity of pain signals going from gut to brain.

Read more about antidepressant medications.

Newer IBS-Targeted Medications Available – There are other medications that are either under study, or have been shown to be effective in treating IBS in multi-center, high quality clinical trials. These are prescription medications intended for specific use under a doctor’s supervision.

Read more about newer IBS medications.


Advancements in our knowledge of the causes of IBS continues to lead to many more effective treatment options. This is accomplished through research and rigorous clinical trials. Treatments can now improve both the pain/discomfort and bowel symptoms experienced by people with IBS. Nonetheless, there is no cure for IBS. It can be difficult to determine which therapy will provide the best efficacy in a patient with IBS. Choosing an appropriate treatment should be a decision made between healthcare provider and you.


Adapted from IFFGD Publication #168, “Current Pharmacologic Treatments for Adults with Irritable Bowel Syndrome”. By: Darren M. Brenner, MD, Associate Professor of Medicine and Surgery, Northwestern University – Feinberg School of Medicine, Chicago, Illinois; Adapted from an article by: Tony Lembo, MD, Professor, of Medicine and Rebecca Rink MS, Beth Israel Deaconess Medical Center, Harvard Medical School, MA; Edited by: Lin Chang, M.D., Professor of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA

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IFFGD is a nonprofit education and research organization. Our mission is to inform, assist, and support people affected by gastrointestinal disorders.

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