Anticholinergic/Antispasmodic Agents

After fiber preparations, antispasmodic agents are the next most commonly prescribed group of medications for the treatment of irritable bowel syndrome (IBS). However, several studies do not provide firm evidence that these agents are efficacious in the IBS population as a whole. Only a few of these antispasmodics have been shown to be more effective than placebo in relieving abdominal pain in some persons (particularly if the symptoms occur soon after eating) in high-quality clinical IBS trials but these are not currently available in the U.S.


Last modified on February 23, 2015, at 07:58:15 AM

Adapted from IFFGD Publication #168 by Anthony J. Lembo, MD, Instructor of Medicine, Harvard Medical School; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA.

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